Peptide lexicon
Pinealon
Tripeptide Glu-Asp-Arg from the group of short peptide bioregulators, studied in neuronal cell and stress models.
| Substance class | Peptide |
|---|---|
| Sequence | EDR |
| CAS number | 175175-23-2 |
| Molecular formula | C₁₅H₂₆N₆O₈ |
| Molar mass | 418.4 g/mol |
| Synonyms | Glu-Asp-Arg |
| PubChem | CID 10273502 |
Structure
Pinealon is the tripeptide EDR. Like other short bioregulators it was described at the St Petersburg Institute of Bioregulation and Gerontology.
Research focus
Studies examine effects on oxidative stress, apoptosis markers and gene expression in neuronal cell cultures and animal models (including prenatal hypoxia). A direct interaction of the peptide with DNA promoter regions is discussed.
Status
The literature comes mostly from one research group. Pinealon is also a component of the neuro blend.
Literature
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's DiseaseMolecules, 2020 · PMID 33396470 · DOI 10.3390/molecules26010159
- Constitutive activity in gonadotropin receptorsAdv Pharmacol, 2014 · PMID 24931192 · DOI 10.1016/B978-0-12-417197-8.00002-X
- [Neuroprotective effects of peptides bioregulators in people of various age]Adv Gerontol, 2013 · PMID 24738258
- The Role of Amino Acids in the Diagnosis, Risk Assessment, and Treatment of Breast Cancer: A ReviewCurr Issues Mol Biol, 2023 · PMID 37754258 · DOI 10.3390/cimb45090474
