Peptide lexicon
Thymosin α1
Thymalfasin, an N-terminally acetylated 28-amino-acid thymic peptide used as an immunomodulator in clinical research.
| Substance class | Peptide |
|---|---|
| Sequence | Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| CAS number | 62304-98-7 |
| Molecular formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molar mass | 3,108.3 g/mol |
| Synonyms | Thymalfasin, Tα1 |
| PubChem | CID 16130571 |
Structure
Thymosin α1 is the N-terminal fragment of prothymosin α and is now produced fully synthetically.
Research focus
Studies examine activation of toll-like receptors on dendritic cells, T-cell maturation and cytokine profiles, and use as an adjuvant in studies on infection and cancer.
Status
Thymalfasin is approved as a medicine in several countries outside the EU; there is no authorisation in the EU.
Literature
- Thymosin alpha-1Am J Health Syst Pharm, 2001 · PMID 11381492 · DOI 10.1093/ajhp/58.10.886
- Thymosin alpha 1 treatment for patients with sepsisExpert Opin Biol Ther, 2018 · PMID 30063866 · DOI 10.1080/14712598.2018.1484104
- Serum thymosin alpha 1 levels in normal and pathological conditionsExpert Opin Biol Ther, 2018 · PMID 30063864 · DOI 10.1080/14712598.2018.1474197
- Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysisFront Immunol, 2025 · PMID 40599771 · DOI 10.3389/fimmu.2025.1571456
- Thymosin alpha 1 and HIV-1: recent advances and future perspectivesFuture Microbiol, 2017 · PMID 28106477 · DOI 10.2217/fmb-2016-0125
