Peptide lexicon
Gonadorelin
Synthetic gonadotropin-releasing hormone (GnRH, LHRH), a hypothalamic decapeptide.
| Substance class | Peptide |
|---|---|
| Sequence | pE-HWSYGLRPG-NH2 |
| CAS number | 33515-09-2 |
| Molecular formula | C₅₅H₇₅N₁₇O₁₃ |
| Molar mass | 1,182.3 g/mol |
| Synonyms | GnRH, LHRH |
| PubChem | CID 638793 |
Structure
Gonadorelin is identical to native GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂). It stimulates the release of LH and FSH from the pituitary.
State of research
Research covers the hypothalamic–pituitary–gonadal axis, pulsatile versus continuous GnRH exposure and GnRH receptor desensitisation.
Status
Gonadorelin is approved as a diagnostic agent and veterinary medicine and is on the WADA Prohibited List (for males).
Literature
- Gonadotropin-Releasing Hormone Receptor (GnRHR) and Hypogonadotropic HypogonadismInt J Mol Sci, 2023 · PMID 37958948 · DOI 10.3390/ijms242115965
- Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International ConsortiumHorm Res Paediatr, 2019 · PMID 31319416 · DOI 10.1159/000501336
- Gonadotropin-releasing hormone analogues for endometriosisCochrane Database Syst Rev, 2023 · PMID 37341141 · DOI 10.1002/14651858.CD014788.pub2
- Control of puberty onset and fertility by gonadotropin-releasing hormone neuronsNat Rev Endocrinol, 2016 · PMID 27199290 · DOI 10.1038/nrendo.2016.70
- Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic reviewFront Endocrinol (Lausanne), 2025 · PMID 40438403 · DOI 10.3389/fendo.2025.1555186
