Peptide lexicon
NAD+
Nicotinamide adenine dinucleotide, a central coenzyme of energy metabolism and substrate of sirtuins, PARP enzymes and CD38.
| Substance class | Coenzyme |
|---|---|
| CAS number | 53-84-9 |
| Molecular formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molar mass | 663.4 g/mol |
| Synonyms | Nicotinamid-Adenin-Dinukleotid, β-NAD |
| PubChem | CID 5892 |
Structure and function
NAD⁺ is a dinucleotide of nicotinamide and adenine mononucleotide. As a redox cofactor it carries electrons in glycolysis, the citric acid cycle and the respiratory chain; it is also consumed by sirtuins, poly(ADP-ribose) polymerases and CD38.
Research focus
Research covers the age-related decline of cellular NAD⁺ levels, precursors such as NMN and nicotinamide riboside, and the influence of NAD⁺ metabolism on mitochondrial function and DNA repair in cell and animal models.
Lab note
NAD⁺ is hygroscopic and sensitive to hydrolysis in solution; the lab reports state the content per vial.
Literature
- NAD(+) metabolism-based immunoregulation and therapeutic potentialCell Biosci, 2023 · PMID 37165408 · DOI 10.1186/s13578-023-01031-5
- NAD(+) metabolism and its roles in cellular processes during ageingNat Rev Mol Cell Biol, 2021 · PMID 33353981 · DOI 10.1038/s41580-020-00313-x
- NAD+ and sirtuins in aging and diseaseTrends Cell Biol, 2014 · PMID 24786309 · DOI 10.1016/j.tcb.2014.04.002
- NAD(+) metabolism, stemness, the immune response, and cancerSignal Transduct Target Ther, 2021 · PMID 33384409 · DOI 10.1038/s41392-020-00354-w
- NAD⁺ in aging, metabolism, and neurodegenerationScience, 2015 · PMID 26785480 · DOI 10.1126/science.aac4854
