Peptide lexicon
Selank
Synthetic heptapeptide (TKPRPGP), an extended analogue of the immune peptide tuftsin, developed at the Institute of Molecular Genetics in Moscow.
| Substance class | Peptide |
|---|---|
| Sequence | TKPRPGP |
| CAS number | 129954-34-3 |
| Molecular formula | C₃₃H₅₇N₁₁O₉ |
| Molar mass | 751.9 g/mol |
| Synonyms | Thr-Lys-Pro-Arg-Pro-Gly-Pro-Pro |
| PubChem | CID 11765600 |
Structure
Selank consists of the tuftsin sequence Thr-Lys-Pro-Arg extended by Pro-Gly-Pro. The C-terminal extension increases stability against peptidases.
Research focus
Studies examine interactions with the GABAergic system, expression of neurotransmission genes and immunomodulatory effects on cytokines. Many studies are in Russian and carried out in animal models.
Status
Selank is registered as a medicine in Russia; there is no authorisation in the EU. N-acetyl selank amidate is a component of the neuro blend.
Literature
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Tuftsin - Properties and AnalogsCurr Med Chem, 2017 · PMID 28745220 · DOI 10.2174/0929867324666170725140826
- [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]Izv Akad Nauk Ser Biol, 2006 · PMID 16634437
- Functional Connectomic Approach to Studying Selank and Semax EffectsDokl Biol Sci, 2020 · PMID 32342318 · DOI 10.1134/S001249662001007X
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in RatsBull Exp Biol Med, 2022 · PMID 36322304 · DOI 10.1007/s10517-022-05624-x
