Peptide lexicon
Semax
Synthetic heptapeptide (MEHFPGP) based on the ACTH fragment 4–7 with a C-terminal Pro-Gly-Pro extension, without hormonal ACTH activity.
| Substance class | Peptide |
|---|---|
| Sequence | MEHFPGP |
| CAS number | 80714-61-0 |
| Molecular formula | C₃₇H₅₁N₉O₁₀S |
| Molar mass | 813.9 g/mol |
| Synonyms | ACTH(4–7)-Pro-Gly-Pro |
| PubChem | CID 9811102 |
Structure
Semax combines the sequence Met-Glu-His-Phe (ACTH 4–7) with the stabilising tripeptide Pro-Gly-Pro. It shows no adrenocorticotropic activity in studies.
Research focus
In animal and cell models Semax is studied in connection with the expression of neurotrophic factors (BDNF, NGF), cerebral ischaemia and gene expression profiles in the brain.
Status
Semax is registered as a medicine in Russia; there is no authorisation in the EU. N-acetyl semax amidate is a component of the neuro blend.
Literature
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Therapeutic peptides in gerontology: mechanisms and applications for healthy agingFront Aging, 2026 · PMID 42021992 · DOI 10.3389/fragi.2026.1790247
- Pharmacological Aspects of Neuro-Immune InteractionsCurr Pharm Des, 2018 · PMID 28875850 · DOI 10.2174/1381612823666170829135115
- Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseasesNeuropeptides, 2025 · PMID 41004910 · DOI 10.1016/j.npep.2025.102563
- [POSSIBLE ROLE OF TRANSTHYRETIN IN THE BIOLOGICAL MECHANISM OF THE REGULATORY PEPTIDE NEUROPROTECTION.]Mol Gen Mikrobiol Virusol, 2016 · PMID 30383932
