Peptide lexicon
SNAP-8
Acetyl octapeptide-3: a synthetic peptide from the N-terminus of the SNARE protein SNAP-25, studied in cosmetic research for neurotransmitter release.
| Substance class | Peptide |
|---|---|
| Sequence | Ac-EEMQRRAD-NH2 |
| CAS number | 868844-74-0 |
| Molecular formula | C₄₁H₇₀N₁₆O₁₆S |
| Molar mass | 1,075.2 g/mol |
| Synonyms | Acetyl Octapeptide-3 |
| PubChem | CID 76283482 |
Structure
SNAP-8 (Ac-EEMQRRAD-NH₂) is a variant of acetyl hexapeptide-3 (argireline) extended by two amino acids. Both mimic a section of SNAP-25.
Research focus
In models the peptide competes with SNAP-25 for SNARE complex formation, reducing exocytosis of acetylcholine vesicles. It is studied mainly in cell models and dermatological formulation studies.
Status
SNAP-8 is listed as a cosmetic ingredient (INCI: Acetyl Octapeptide-3).
Literature
- Cosmeceuticals in photoaging: A reviewSkin Res Technol, 2024 · PMID 39233460 · DOI 10.1111/srt.13730
- Complications and adverse effects of periocular aesthetic treatmentsSurv Ophthalmol, 2022 · PMID 33933438 · DOI 10.1016/j.survophthal.2021.04.009
- Facial rejuvenation: combining cosmeceuticals with cosmetic proceduresCutis, 2014 · PMID 25279473
- A synthetic hexapeptide (Argireline) with antiwrinkle activityInt J Cosmet Sci, 2002 · PMID 18498523 · DOI 10.1046/j.1467-2494.2002.00153.x
- Public Interest in Acetyl Hexapeptide-8: Longitudinal AnalysisJMIR Dermatol, 2024 · PMID 38376906 · DOI 10.2196/54217
