Peptide lexicon
TB-500 (Thymosin β4)
Synthetic thymosin β4 (43 amino acids), an actin-binding peptide studied in models of cell migration, angiogenesis and wound healing.
| Substance class | Peptide |
|---|---|
| Sequence | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES |
| CAS number | 77591-33-4 |
| Molecular formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molar mass | 4,963 g/mol |
| Synonyms | Thymosin β4, Tβ4 |
| PubChem | CID 45382195 |
Structure
Thymosin β4 (Tβ4) is an N-terminally acetylated peptide of 43 amino acids and one of the most abundant intracellular peptides. In research supply, TB-500 usually refers to the synthetic full-length peptide; the name is sometimes also used for the short actin-binding fragment LKKTETQ (Tβ4 17–23). The lab reports for Peptidkauf batches test for Tβ4.
Mechanism in models
Tβ4 sequesters monomeric G-actin and so influences cytoskeletal dynamics. Preclinical work studies cell migration, angiogenesis, modulation of inflammation and tissue repair in skin, cornea and heart muscle.
Status
Clinical studies have focused mainly on topical formulations (cornea, skin). WADA lists thymosin β4 and its fragments in category S2 (peptide hormones, growth factors).
Literature
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformanceSports Med, 2026 · PMID 41966639 · DOI 10.1007/s40279-026-02437-0
- beta-ThymosinsAnn N Y Acad Sci, 2007 · PMID 17468232 · DOI 10.1196/annals.1415.018
- The beta-thymosin enigmaAnn N Y Acad Sci, 2007 · PMID 17495248 · DOI 10.1196/annals.1415.021
- Thymosin β(4) and β(10) Expression in Human Organs during Development: A ReviewCells, 2024 · PMID 38994967 · DOI 10.3390/cells13131115
- [Biomolecules suppressing myelopoiesis]Acta Cient Venez, 1992 · PMID 1343739
