Peptide lexicon
5-Amino-1MQ
Cell-permeable inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a quinolinium derivative from metabolic research.
| Substance class | Small Molecule |
|---|---|
| CAS number | 685079-15-6 |
| Molecular formula | C₁₀H₁₁N₂+ |
| Molar mass | 159.21 g/mol |
| Synonyms | 5-Amino-1-methylchinolinium, NNMT-Inhibitor |
| PubChem | CID 950107 |
Structure
5-Amino-1-methylquinolinium is a small, positively charged molecule (small molecule), not a peptide. It has been described as a selective NNMT inhibitor.
Research focus
NNMT methylates nicotinamide and thereby affects NAD⁺ and methyl-group metabolism. In adipocyte cultures and animal models, researchers study how inhibiting the enzyme changes lipogenesis, energy expenditure and cellular NAD⁺ levels.
Status
The data come from preclinical studies. In the NAD+ + MOTS-c + 5-Amino-1MQ blend, 5-Amino-1MQ is combined with MOTS-c and NAD⁺.
Literature
- Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic targetDrug Discov Today, 2021 · PMID 34029690 · DOI 10.1016/j.drudis.2021.05.011
- Mechanisms and inhibitors of nicotinamide N-methyltransferaseRSC Med Chem, 2021 · PMID 34458733 · DOI 10.1039/d1md00016k
- Gastric Cancer in the Era of EpigeneticsInt J Mol Sci, 2024 · PMID 38542354 · DOI 10.3390/ijms25063381
- [Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease]Nihon Yakurigaku Zasshi, 2000 · PMID 11188501 · DOI 10.1254/fpj.116.333
- Parkinson's disease: the first common neurological disease due to auto-intoxication?QJM, 2005 · PMID 15728403 · DOI 10.1093/qjmed/hci027
