Peptide lexicon
Epithalon
Tetrapeptide Ala-Glu-Asp-Gly (epitalon), a synthetic analogue of a pineal gland extract, studied in connection with telomerase and cellular ageing.
| Substance class | Peptide |
|---|---|
| Sequence | AEDG |
| CAS number | 307297-39-8 |
| Molecular formula | C₁₄H₂₂N₄O₉ |
| Molar mass | 390.35 g/mol |
| Synonyms | Epitalon, Ala-Glu-Asp-Gly |
| PubChem | CID 219042 |
Structure
Epithalon is the tetrapeptide AEDG. It was developed as the synthetic counterpart of the pineal extract epithalamin.
Research focus
Publications describe telomerase activation and telomere elongation in cell culture, effects on the melatonin rhythm and lifespan endpoints in animal models. Binding to DNA promoter regions is discussed.
Status
The literature comes mostly from one research group; independent replication is limited. No marketing authorisation.
Literature
- Peptides and AgeingNeuro Endocrinol Lett, 2002 · PMID 12374906
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising PropertiesInt J Mol Sci, 2025 · PMID 40141333 · DOI 10.3390/ijms26062691
- Therapeutic peptides in gerontology: mechanisms and applications for healthy agingFront Aging, 2026 · PMID 42021992 · DOI 10.3389/fragi.2026.1790247
- [Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]Adv Gerontol, 2024 · PMID 39742404
