Peptide lexicon
AOD-9604
Modified C-terminal fragment of human growth hormone (hGH 177–191 with an N-terminal tyrosine), studied in models of fat metabolism.
| Substance class | Peptide |
|---|---|
| Sequence | YLRIVQCRSVEGSCGF |
| CAS number | 221231-10-3 |
| Molecular formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molar mass | 1,815.1 g/mol |
| Synonyms | hGH(176–191)-Analogon |
| PubChem | CID 71300630 |
Structure
AOD-9604 corresponds to amino acids 177–191 of hGH with an added N-terminal tyrosine and contains a disulfide bridge. The fragment does not bind the GH receptor to any relevant extent and did not affect IGF-1 in studies.
Research focus
Preclinical work examines effects on lipolysis and lipogenesis in fat cells. Clinical weight-loss trials ended without a marketing application; there is also work on cartilage models.
Status
No marketing authorisation in the EU. WADA lists GH fragments in category S2.
Literature
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformanceSports Med, 2026 · PMID 41966639 · DOI 10.1007/s40279-026-02437-0
- Obesity drugs in clinical developmentCurr Opin Investig Drugs, 2006 · PMID 16625817
- AOD-9604 MetabolicCurr Opin Investig Drugs, 2004 · PMID 15134286
- Current updates in the medical management of obesityRecent Pat Endocr Metab Immune Drug Discov, 2012 · PMID 22435392 · DOI 10.2174/187221412800604644
