Peptide lexicon
SLU-PP-332
Synthetic pan-agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ (small molecule), studied in models of mitochondrial metabolism.
| Substance class | Small Molecule |
|---|---|
| CAS number | 303760-60-3 |
| Molecular formula | C₁₈H₁₄N₂O₂ |
| Molar mass | 290.3 g/mol |
| Synonyms | ERRα/β/γ-Agonist |
| PubChem | CID 5338394 |
Structure
SLU-PP-332 is a small organic molecule, not a peptide. It was described at Saint Louis University as an agonist of the nuclear receptors ERRα/β/γ, which control the expression of genes for mitochondrial biogenesis and oxidative phosphorylation.
Research focus
Mouse models study how ERR activation changes the proportion of oxidative muscle fibres, fatty acid oxidation and endurance, which is why the compound is discussed as an 'exercise mimetic'.
Status
The data are preclinical. Peptidkauf supplies SLU-PP-332 as lyophilized powder and in tablet form.
Literature
- [Pharmacological Activation of ERRα/β/γ as an Exercise Mimetic: Potential Therapeutic Applications]Rev Med Chil, 2026 · PMID 42024694 · DOI 10.4067/s0034-98872026000200237
- A Synthetic ERR Agonist Alleviates Metabolic SyndromeJ Pharmacol Exp Ther, 2024 · PMID 37739806 · DOI 10.1124/jpet.123.001733
- Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial FunctionCirculation, 2024 · PMID 37961903 · DOI 10.1161/CIRCULATIONAHA.123.066542
- An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacityJ Pharmacol Exp Ther, 2026 · PMID 41421047 · DOI 10.1016/j.jpet.2025.103787
- Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915Eur J Med Chem, 2023 · PMID 37421886 · DOI 10.1016/j.ejmech.2023.115582
