What is Sobetirome (GC-1)?
Sobetirome is a small molecule (C₂₀H₂₄O₄) modelled on thyroid hormone but without iodine, preferentially activating the β isoform of the receptor.
More data in the lexicon entry on Sobetirom.
State of research
Sobetirome was developed in the 1990s by Thomas Scanlan at the University of California. The idea: the α form of the thyroid hormone receptor mainly controls heart rate and muscle, the β form mainly liver and cholesterol metabolism. A β-selective compound could lower blood lipids without stressing the heart.
In animal models and an early clinical study sobetirome lowered LDL cholesterol. Later, myelin research came to the fore: in mouse models it promoted regeneration of the nerve's protective sheath, and clinical development began for the rare inherited disease X-linked adrenoleukodystrophy. Related compounds of this class are now approved for liver disease.
Status and quality
Sobetirome is not approved as a medicine. Peptidkauf sells Sobetirome (GC-1) solely as a research reagent for laboratory and in-vitro use and gives no dosing or application advice.
An independent laboratory tests every batch for purity (HPLC), identity and measured content before it goes on sale; the reports and their verification keys are in the lab report archive. The material ships as lyophilised powder in a glass vial; storage and laboratory handling are covered under storage & handling.
Related products and articles
More metabolic research: SLU-PP-332, 5-amino-1MQ, MOTS-c. Thyroid axis: TRH.
