Peptide lexicon
Sobetirom (GC-1)
Selective agonist at thyroid hormone receptor β (GC-1), a thyromimetic.
| Substance class | Small Molecule |
|---|---|
| CAS number | 211110-63-3 |
| Molecular formula | C₂₀H₂₄O₄ |
| Molar mass | 328.4 g/mol |
| Synonyms | GC-1, Thyroidhormon-Rezeptor-β-Agonist |
| PubChem | CID 9862248 |
Structure
Sobetirome is a small molecule (C₂₀H₂₄O₄) modelled on thyroid hormone but without iodine, preferentially activating the β isoform of the receptor.
State of research
Research covers hepatic cholesterol and lipid metabolism, myelin repair in demyelination models and the separation of cardiac and metabolic effects.
Status
Sobetirome is not approved as a medicinal product.
Literature
- Thyroid Hormone Analogues: An UpdateThyroid, 2020 · PMID 32098589 · DOI 10.1089/thy.2020.0071
- Sobetirome: a selective thyromimetic for the treatment of dyslipidemiaRecent Pat Cardiovasc Drug Discov, 2011 · PMID 21208155 · DOI 10.2174/157489011794578473
- Thyroid hormone metabolites and analoguesEndocrine, 2019 · PMID 31359245 · DOI 10.1007/s12020-019-02025-5
- Sobetirome: a case history of bench-to-clinic drug discovery and developmentHeart Fail Rev, 2010 · PMID 19002578 · DOI 10.1007/s10741-008-9122-x
- Metabolic effects of thyroid hormone derivativesThyroid, 2008 · PMID 18279024 · DOI 10.1089/thy.2007.0248
