Peptide lexicon
N-Acetyl Selank Amidat
N-terminally acetylated, C-terminally amidated form of Selank, a tuftsin analogue.
| Substance class | Peptide |
|---|---|
| Sequence | Ac-TKPRPGP-NH2 |
| Synonyms | NA-Selank-NH2 |
Structure
N-Acetyl Selank Amidate carries the Selank sequence (TKPRPGP) with terminal modifications intended to slow degradation by exopeptidases.
State of research
As with Selank, research covers GABAergic and serotonergic effects, cytokine expression and behavioural anxiety models. Data on the modified form are limited.
Status
N-Acetyl Selank is not approved as a medicinal product.
Literature
- Tuftsin - Properties and AnalogsCurr Med Chem, 2017 · PMID 28745220 · DOI 10.2174/0929867324666170725140826
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in RatsBull Exp Biol Med, 2022 · PMID 36322304 · DOI 10.1007/s10517-022-05624-x
- Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in RatsBull Exp Biol Med, 2019 · PMID 31625062 · DOI 10.1007/s10517-019-04588-9
- The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank actionMol Immunol, 2014 · PMID 24291245 · DOI 10.1016/j.molimm.2013.11.002
- Expression of inflammation-related genes in mouse spleen under tuftsin analog SelankRegul Pept, 2011 · PMID 21609736 · DOI 10.1016/j.regpep.2011.05.001
