Peptide lexicon
DSIP
Delta sleep-inducing peptide, a nonapeptide (WAGGDASGE) isolated in 1977 from the blood of rabbits in a sleep state.
| Substance class | Peptide |
|---|---|
| Sequence | WAGGDASGE |
| CAS number | 62568-57-4 |
| Molecular formula | C₃₅H₄₈N₁₀O₁₅ |
| Molar mass | 848.8 g/mol |
| Synonyms | Delta Sleep-Inducing Peptide |
| PubChem | CID 68816 |
Structure and origin
DSIP was originally described as a factor promoting delta waves in the EEG in animal models. A specific gene or receptor has not been clearly identified to date.
Research focus
Studies examined effects on sleep architecture, stress response, thermoregulation and the endocrine system. Results are inconsistent; many studies date from the 1980s and 1990s.
Status
No marketing authorisation.
Literature
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJ Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI 10.5435/JAAOSGlobal-D-25-00236
- Delta sleep-inducing peptideEur J Anaesthesiol, 2001 · PMID 11437870 · DOI 10.1046/j.1365-2346.2001.00917.x
- Delta-sleep-inducing peptide (DSIP): a reviewNeurosci Biobehav Rev, 1984 · PMID 6145137 · DOI 10.1016/0149-7634(84)90022-8
- Delta sleep-inducing peptide (DSIP): a still unresolved riddleJ Neurochem, 2006 · PMID 16539679 · DOI 10.1111/j.1471-4159.2006.03693.x
- Delta-sleep-inducing peptide (DSIP): an updatePeptides, 1986 · PMID 3550726 · DOI 10.1016/0196-9781(86)90148-8
