Peptide lexicon
Bronchogen
Synthetic tetrapeptide (Ala-Glu-Asp-Leu) from the group of peptide bioregulators, associated with bronchial tissue.
| Substance class | Peptide |
|---|---|
| Sequence | AEDL |
| Molecular formula | C₁₈H₃₀N₄O₉ |
| Molar mass | 446.44 g/mol |
| Synonyms | Ala-Glu-Asp-Leu |
Structure
Bronchogen consists of alanine, glutamic acid, aspartic acid and leucine and belongs to the short peptides of the Khavinson research.
State of research
Studies examined gene expression and differentiation of bronchial epithelial cells and airway inflammation models in animals.
Status
Bronchogen is not approved as a medicinal product; studies come mainly from one research group.
Literature
- Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung PathologyBull Exp Biol Med, 2015 · PMID 26468022 · DOI 10.1007/s10517-015-3047-x
- [ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY]Ross Fiziol Zh Im I M Sechenova, 2017 · PMID 30199201
- Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostabilityBull Exp Biol Med, 2011 · PMID 21240358 · DOI 10.1007/s10517-011-1146-x
- Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacumBiochemistry (Mosc), 2017 · PMID 28371610 · DOI 10.1134/S0006297917040149
- Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNABiochemistry (Mosc), 2011 · PMID 22117547 · DOI 10.1134/S0006297911110022
