Peptide lexicon
Testagen
Tetrapeptide Lys-Glu-Asp-Gly from the group of short peptide bioregulators, studied in cell models.
| Substance class | Peptide |
|---|---|
| Sequence | KEDG |
| Molecular formula | C₁₇H₂₉N₅O₉ |
| Molar mass | 447.44 g/mol |
| Synonyms | Lys-Glu-Asp-Gly |
Structure
Testagen is the tetrapeptide KEDG (C₁₇H₂₉N₅O₉, 447.4 g/mol, calculated from the sequence). It belongs to the synthetic short peptides of the St Petersburg Institute of Bioregulation and Gerontology.
Research focus
Publications describe effects on gene expression and proliferation markers in cell culture. As with other bioregulators, an interaction with DNA is discussed.
Status
The evidence is very limited and comes mostly from one research group.
Literature
- Peptide Regulation of Cell DifferentiationStem Cell Rev Rep, 2020 · PMID 31808038 · DOI 10.1007/s12015-019-09938-8
- Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNABiochemistry (Mosc), 2011 · PMID 22117547 · DOI 10.1134/S0006297911110022
- Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family TransportersBiomolecules, 2023 · PMID 36979488 · DOI 10.3390/biom13030552
- Effect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birdsBull Exp Biol Med, 2013 · PMID 23658898 · DOI 10.1007/s10517-013-2029-0
- Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hensBull Exp Biol Med, 2011 · PMID 22268052 · DOI 10.1007/s10517-011-1177-3
