Peptide lexicon
Cortagen
Tetrapeptide Ala-Glu-Asp-Pro from the group of short peptide bioregulators, studied in models of nervous tissue.
| Substance class | Peptide |
|---|---|
| Sequence | AEDP |
| CAS number | 335591-03-2 |
| Molecular formula | C₁₇H₂₆N₄O₉ |
| Molar mass | 430.4 g/mol |
| Synonyms | Ala-Glu-Asp-Pro |
| PubChem | CID 18439621 |
Structure
Cortagen is the tetrapeptide AEDP. It belongs to the synthetic short peptides derived from studies of brain tissue extracts.
Research focus
Publications describe effects on gene expression and regeneration in models of peripheral nerve injury and in cell culture. As with other bioregulators, an interaction with DNA is discussed.
Status
The literature comes mostly from one research group; independent studies are rare.
Literature
- Tissue-specific effects of peptidesBull Exp Biol Med, 2001 · PMID 11713572 · DOI 10.1023/a:1013058701974
- Effects of bioactive tetrapeptides on free-radical processesBull Exp Biol Med, 2007 · PMID 18239817 · DOI 10.1007/s10517-007-0230-8
- Effects of short peptides on lymphocyte chromatin in senile subjectsBull Exp Biol Med, 2004 · PMID 15085253 · DOI 10.1023/b:bebm.0000024393.40560.05
- Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathwayBull Exp Biol Med, 2002 · PMID 12420072 · DOI 10.1023/a:1019830308824
- Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptidesBull Exp Biol Med, 2005 · PMID 16224591 · DOI 10.1007/s10517-005-0388-x
