Peptide lexicon
Pancragen
Synthetic tetrapeptide (Lys-Glu-Asp-Trp) from the group of peptide bioregulators, associated with the pancreas.
| Substance class | Peptide |
|---|---|
| Sequence | KEDW |
| Molecular formula | C₂₆H₃₆N₆O₉ |
| Molar mass | 576.61 g/mol |
| Synonyms | Lys-Glu-Asp-Trp |
Structure
Pancragen consists of lysine, glutamic acid, aspartic acid and tryptophan and is described as a bioregulator of the pancreas.
State of research
Studies examined the expression of differentiation factors in pancreatic cell cultures and metabolic parameters in animal models.
Status
Pancragen is not approved as a medicinal product; studies come mainly from one research group.
Literature
- [Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys]Adv Gerontol, 2015 · PMID 28509500
- Effects of pancragen on the differentiation of pancreatic cells during their ageingBull Exp Biol Med, 2013 · PMID 23486591 · DOI 10.1007/s10517-013-1987-6
- Prospects of using pancragen for correction of metabolic disorders in elderly peopleBull Exp Biol Med, 2011 · PMID 22448364 · DOI 10.1007/s10517-011-1354-4
- Peptides tissue-specifically stimulate cell differentiation during their agingBull Exp Biol Med, 2012 · PMID 22808515 · DOI 10.1007/s10517-012-1664-1
- [The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats]Adv Gerontol, 2006 · PMID 17152728
